![]() ![]() Brain sections were rendered translucent so that entire hippocampi could be reconstructed and all fluorescently labeled cells identified. Mice were examined 2 months after pilocarpine-induced status epilepticus, a treatment that leads to the development of epilepsy. To explore this question, we conducted a clonal analysis study in mice expressing the Brainbow fluorescent protein reporter construct in dentate granule cell progenitors. Although it has been established that these abnormal cells are newly generated, it is not known whether they arise ubiquitously throughout the progenitor cell pool or are derived from a smaller number of “bad actor” progenitors. The new cells migrate to ectopic locations and develop misoriented “basal” dendrites. During the development of epilepsy, granule cell integration is profoundly altered. ![]() In the normal brain, new granule cells are generated from progenitors in the subgranular zone and integrate in a typical fashion. Hippocampal dentate granule cells are among the few neuronal cell types generated throughout adult life in mammals. ![]()
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